Job offer in england Novel Approaches to Assess Cellular Interactions and Their Role in the Pathology and Treatment of Lymphoproliferative Disorders at University of Plymouth

University of Plymouth

PhD Studentship available full-time or part-time

Start date: October 2017

Dos: Dr Claire Hutchinson

2nd Supervisor: Professor Simon Rule

The Plymouth University Peninsula Schools of Medicine & Dentistry are seeking to attract PhD candidates of outstanding ability to join their exciting and rapidly expanding programme of internationally-rated research. The Plymouth University Peninsula Schools of Medicine & Dentistry are committed to research excellence with a recent £25 million investment in staff and facilities. Medical research at PUPSMD was ranked first for outputs in REF2014.

Applications are invited from suitably qualified graduates, 2:1 or above. International students must also have an IELTS score of 7.0 or above (with no less than 6.5 in any element).

Chronic lymphocytic leukaemia and mantle cell lymphoma are distinctive blood cancers where movement and adhesion of the abnormal cells play a major role in the development of the disease and in the response to therapy. This project looks at how new therapies affect these processes.

The PhD project will take place within an established research group that is linked to an active Clinical Trials Unit, which is nationally recognised for the treatment of mantle cell lymphoma, and a dedicated chronic lymphocytic leukaemia clinic both based within Derriford Hospital. This work uses cells grown in laboratory culture that model the leukaemia/lymphoma including the supporting cells that form the “tumour microenvironment” which aids the growth and survival of the abnormal, neoplastic cells. The behaviour of cells will be assessed using specific functional assays including fluorescence microscopy, flow cytometry and live cell imaging, and focus on defining cell responses quantitatively so they can be compared and statistically evaluated. The work will particularly assess responses to new drug treatments aimed at modifying cell signalling. The aim is to develop a detailed understanding of how novel new drugs work to inform monitoring of treatment-response and the development of new therapeutic strategies.

For further information regarding the project, please contact Dr Claire Hutchinson However, applications must be made in accordance with the details shown below.

Funding Notes:

The stipend will be approx. £14,553 per annum. Tuition fees will be paid at the home/EU rate. Candidates who are not eligible for Home/EU fees will be liable for the difference between ‘home student fees’ and ‘international student fees’. For the 16/17 academic year the difference in fee is (approx. £10350 per annum.) If you are selected you will be required to provide financial assurances.

To Apply:

Follow the link and click ‘Apply’ to access the application form.  Please mark the application for the attention of Francesca Niedzielski stating the PUPSMD-16-17-011 reference number. Please Note:  you do not need to submit a project proposal with your application.

Further information on the application process. If you have any questions on the admissions process contact  

The closing date for applications is 12 noon on 02 06 2017. Shortlisted candidates will be invited for interview. We regret that we may not be able to respond to all applications.  Applicants who have not received an offer of a place by (07 07 2017) should consider their application has been unsuccessful on this occasion.

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