Job offer in london Research Associate at Imperial College London
Our project aims to investigate disease modelling in knockin mouse models carrying two mutations (missense and nonsense mutations) in the Popeye domain containing (POPDC) genes discovered in patients suffering from Limb-Girdle Muscular Dystrophy (LGMD) and/or Cardiac Arrhythmia. The POPDC genes encode a family of cAMP effector proteins, which are involved in the physiological response to stress but are also important for the maintenance of homeostasis and the structural aspects of cardiac myocytes and skeletal muscle cells.
The post holder will conduct and help design experiments using mouse mutants and their wildtype litter mates. He/she will also be involved in the genotyping and maintenance of the respective mouse lines.
We are looking for a highly motivated postdoctoral researcher who has first-hand experience with cyclic nucleotide signalling (FRET analysis of cAMP nanodomains) in isolated and/or cultured cardiac myocytes. Analysis of cardiac pacemaking by optical recording of tissue preparations, or patch clamp analysis of isolated cardiac myocytes or sinus node myocytes.
Practical experience with mouse models and their functional analysis using ECG and MRI. Experience of cardiac biology and imaging and cell culture techniques are required. Moreover, basic biochemistry (Western blotting), molecular biology (cell transfection, mutagenesis, sequencing) as well as immunoconfocal analysis is expected. Experience with paraffin histology, cryosections, electron microscopy or high-resolution microscopy would be desirable.
This post is full time and fixed term (start 1 May 2019 until 30 April 2022).
The Salary structure is subject to change effective from 1st April 2019, please see full details on our salary structure reform
For technical issues when applying online please email email@example.com
Should you have any queries please contact:
Professor Thomas Brand firstname.lastname@example.org
Committed to equality and valuing diversity, we are also an Athena SWAN Silver Award winner, a Stonewall Diversity Champion, a Disability Confident Employer and are working in partnership with GIRES to promote respect for trans people.
The College is a proud signatory to the San-Francisco Declaration on Research Assessment (DORA), which means that in hiring and promotion decisions, we evaluate applicants on the quality of their work, not the journal impact factor where it is published. For more information, see https://www.imperial.ac.uk/research-and-innovation/about-imperial-research/research-evaluation/
The College believes that the use of animals in research is vital to improve human and animal health and welfare. Animals may only be used in research programmes where their use is shown to be necessary for developing new treatments and making medical advances. Imperial is committed to ensuring that, in cases where this research is deemed essential, all animals in the College’s care are treated with full respect, and that all staff involved with this work show due consideration at every level. http://www.imperial.ac.uk/research-and-innovation/about-imperial-research/research-integrity/animal-research/