Job offer in london Research Associate at Imperial College London
Our project aims to investigate disease modelling in knockin mouse models carrying two mutations (missense and nonsense mutations) in the Popeye domain containing (POPDC) genes discovered in patients suffering from Limb-Girdle Muscular Dystrophy (LGMD) and/or Cardiac Arrhythmia. The POPDC genes encode a family of cAMP effector proteins, which are involved in the physiological response to stress but are also important for the maintenance of homeostasis and the structural aspects of cardiac myocytes and skeletal muscle cells.
The post holder will conduct and help design experiments using mouse mutants and their wildtype litter mates. He/she will also be involved in the genotyping and maintenance of the respective mouse lines.
We are looking for a highly motivated postdoctoral researcher who has first-hand experience with cyclic nucleotide signalling (FRET analysis of cAMP nanodomains) in isolated and/or cultured cardiac myocytes. Analysis of cardiac pacemaking by optical recording of tissue preparations, or patch clamp analysis of isolated cardiac myocytes or sinus node myocytes.
Practical experience with mouse models and their functional analysis using ECG and MRI. Experience of cardiac biology and imaging and cell culture techniques are required. Moreover, basic biochemistry (Western blotting), molecular biology (cell transfection, mutagenesis, sequencing) as well as immunoconfocal analysis is expected. Experience with paraffin histology, cryosections, electron microscopy or high-resolution microscopy would be desirable.
This post is full time and fixed term (start 1 May 2019 until 30 April 2022).
The Salary structure is subject to change effective from 1st April 2019, please see full details on our salary structure reform
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