Job offer in england Research Fellow (81461-018) at University of Warwick



University of Warwick – Life Sciences

Fixed term contract 

Funding at level 6 (£29,799 – £38,833) is available for a maximum of 24 months; this might have to be shortened up to a maximum contract length of 21.5 months depending on the starting salary of the successful candidate. 

This project aims to explore the clinical potential of a historical anti-infection cocktail, with a view to isolating active compounds and assessing their likely efficacy and safety as topical agents to prevent and treat diabetic foot infections (DFI). We are seeking a post-doctoral researcher to conduct in vitro studies of the biological activities of this natural product cocktail, with the ultimate goal of working with Warwick’s Clinical Trials Unit to conduct a pilot safety trial.

You will (i) screen the ancientbiotic and its chemical fractions for activity against a panel of key aerobic and anaerobic DFI pathogens, in simple in vitro assays and in high-validity models of polymicrobial biofilm infection; (ii) provide conceptual and technical input into research exploring the mechanism of action of the ancientbiotic; (iii) assess the toxicity and immunomodulatory activity of the ancientbiotic and its active constituents towards human epithelial cells and monocytes in cell culture; and (iv) assist in the design, implementation and analysis of pilot safety trials (patch testing) in healthy volunteers. Background information on the natural product cocktail may be found in Harrison et al. (2015) mBio 6:e01129-15.

The post will be based primarily in the research group of Dr Freya Harrison (School of Life Sciences) with significant collaboration with Dr Meera Unnikrishnan and Prof. Julie Bruce (Warwick Medical School). This role also involves communicating with collaborators who will be conducting chemical fractionation and analysis of the ancientbiotic (Prof David Barrett, University of Nottingham), and conducting in vivo tests of its antibacterial efficacy (Dr Kendra Rumbaugh, Texas Tech University).

The ideal candidate should have experience in microbiology (preferably working with pathogenic bacteria in a containment lab), cell culture and data analysis. Because this project is part of an interdisciplinary consortium, and because it involves the potential to interact with volunteers taking part in safety tests, the ideal candidate will also be able to demonstrate excellent communication and teamwork skills.

Please submit your application including your CV and a covering letter stating why you are interested in the topic and what you would bring to the project. For informal enquires or more information about the project, please contact freya.harrison@warwick.ac.uk.

Full details of the duties and selection criteria for this role are found in the vacancy advert on the University of Warwick jobs page. You will be routed to this when you click on the Apply button below.

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Location(s):

Midlands of England

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