Job offer in england Postdoctoral Fellow (Statistical Genetics) – Wellcome Trust Sanger Institute

Fixed term for 3 years 

Our group has a long-standing interest in the genetics of inflammatory bowel disease (IBD). IBD is a chronic, debilitating disorder of the gastrointestinal tract that affects around 0.5% of the population, with a typical onset in early adulthood. Many IBD patients ultimately require major abdominal surgery, resulting in lifelong disability, because an appropriate drug either does not exist or is not administered soon enough. Total healthcare costs in the UK are estimated to be over £1 billion per year. IBD pathogenesis is poorly understood but is likely driven by a dysregulated immune response to commensal gut microorganisms in genetically susceptible individuals. IBD is highly heritable and our group has played a leading role in the identification of 240 regions of the genome associated with disease susceptibility.

We are looking to appoint a statistical or computational postdoctoral fellow with an interest in complex disease genetics to take the lead on one of our large-scale sequencing based studies. As part of the UK IBD Genetics Consortium we are currently whole-genome sequencing over 15,000 IBD cases and 20,000 population controls at >15X coverage. This will enable us, for the first time, to powerfully test the entire allelic spectrum for association to IBD. Data from this project will be combined with that from multi-omic studies of disease-relevant cell types to identify new therapeutic targets for IBD.

The fellow will join a multi-disciplinary team of statisticians, geneticists, immunologists, computer scientists and clinicians who work together to understand the genetics and genomics of immune-mediated disease. The fellow will help shape the future direction of the research group and have the opportunity to develop their own research projects within the scope of the group’s interests. Supervisor – Dr Carl Anderson

Essential Skills

  • PhD in a relevant quantitative subject (e.g. Genetics/Genomics, Statistics, Computational Biology)
  • Proficient programmer (e.g. Perl, Python, R) and user of cluster computing
  • Demonstrable statistical skills with experience of analysing large-scale genetic/genomic data (e.g. 100s/1000s of individuals with sequencing/GWAS data)
  • Motivation and ambition to make a personal contribution to genomic research
  • A passion for problem solving and creative thinking
  • A paper-oriented approach to scientific research
  • Clear communicator with experience of writing scientific manuscripts
  • An independent working style with high self-motivation
  • Ability to work with others in a friendly and collegiate environment

Other Information

The Sanger Institute is a charitably funded research centre focused on understanding the role of genetics in health and disease. We use state of the art large-scale genomic approaches to drive world-leading projects to uncover the basis of genetic and infectious disease. Our goal is to provide results that can be translated into diagnostics, treatments or therapies that reduce global health burdens.

The Institute is located near Cambridge, UK on the stunning Wellcome Genome Campus. This growing and dynamic site is the British hub of genomic science. It hosts the European Bioinformatics Institute (EBI), Open Targets, a Biodata Innovation Centre and will soon host Genomics England Limited’s 100,000 Genomes Sequencing Centre. The Campus is also home to Wellcome Genome Campus Connecting Science. Connecting Science inspires new thinking, sparks conversation and supports learning by drawing on the ground-breaking research taking place on the Campus. Its mission is to enable everyone to explore genomic science and its impact on research, health and society.

To help researchers to develop their skills and networks, the Institute hosts a range of scientific seminars with internal and invited speakers, scientific group meetings and skills development workshops.

Our Benefits include: Defined Contribution Pension Scheme, Group Income Protection, Healthcare scheme, Childcare Vouchers, Workplace Nursery and 25 days Annual Leave, increasing by one day per year up to a maximum of 30, plus Bank Holidays. We also have a gym, two cafes, dining facilities, and a free campus bus service. Our thriving Sports and Social Club provides many opportunities to meet with people working across the campus.

Wellcome Trust Sanger Institute welcomes applications from all candidates irrespective of age, disability, gender, gender identity, sexual orientation, race, religion or belief, or marital or civil partnership status.

Please include a covering letter and CV with your application.  

Closing date for applications: 17th January 2018.